Summary
This is a Phase 3 prospective, randomized, superiority, open-label, multi-site study. The
overview of this study is as follows:
- A Screening/Baseline Period of 21 days. During this time, patients will be
randomized into a 1:2 allocation of Arm A:Arm B.
- A Perioperative/Operative Phase where patients will undergo tumor resection (Arm A)
or tumor resection plus GammaTile implantation (Arm B).
- An EBRT Prior to Start Period. This occurs within 10 business days prior to EBRT and
Concurrent TMZ Phase.
- An EBRT and Concurrent TMZ Phase, which will begin 30 ±10 days post-surgery. EBRT
(30 fractions) and TMZ will be administered up to 5 days a week for 6 weeks in Arm
A, and EBRT (20 fractions) and TMZ will be administered for up to 5 days a week for
4 weeks in Arm B. TMZ will be administered at a dose of 75 mg/m2/day orally for each
Arm.
- An Adjuvant TMZ Phase, which begins 28 ±7 days following the EBRT and Concurrent TMZ
Phase, and is comprised of six 28-day cycles. TMZ (150-200 mg/m2/day orally) will be
administered for the first 5 days of each 28-day cycle for each Arm. Tumor treating
fields are allowed but are not mandated during this phase. Up to 6 additional cycles
(for a total of 12) can be completed at the discretion of the Investigator.
- An Early Discontinuation/Follow-Up Phase will occur 28 ±7 days after completion of
Cycle 6 of the Adjuvant TMZ Phase, regardless of the total number of cycles
completed or any delays in cycle start. If fewer than six cycles are completed, the
first follow-up assessment will occur 28 ±7 days after the last administered dose of
adjuvant TMZ. If patient has a qualifying event requiring entrance to Early
Discontinuation Phase, the first follow-up assessment will occur as soon as
feasible, but within 28 days.
For any unscheduled visits, data collected should be documented in the case report form
(CRF) and must include, but are not limited to, safety evaluations, survival status, and
disease status.