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A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer


Active: Yes
Cancer Type: Gynecologic Cancers
Ovarian Cancer
Primary Peritoneal Cancer
Unknown Primary
NCT ID: NCT07213804
Trial Phases: Phase III Protocol IDs: 27727 (primary)
NCI-2026-00146
2025-522255-25-00
APGOT-OV17
ENGOT-ov97/GINECO-NOGGO
GOG-3133
J5E-MC-JZXB
Eligibility: 18 Years and older, Male and Female Study Type: Treatment
Study Sponsor: Eli Lilly and Company
NCI Full Details: http://clinicaltrials.gov/show/NCT07213804

Summary

This is a clinical study that has three parts. It is testing a potential new medicine
called Sofetabart Mipitecan (Sofe-M) for people with certain types of ovarian,
peritoneal, and fallopian tube cancers. Part A enrolls participants with
platinum-resistant cancer, meaning their disease progressed during or within six months
of platinum-based chemotherapy. Parts B and C enroll participants with platinum-sensitive
cancer, whose disease responded and remained controlled for at least six months after
completing platinum treatment. The researchers want to find out if Sofe-M works better
than the standard treatments that doctors use now and to better understand how safe it
is. Each participant's time in the study will depend on how they respond to the
treatment.

Treatment Sites in Georgia

Nancy N. and J.C. Lewis Cancer Research Pavilion at St. Joseph Candler
225 Candler Drive
Savannah, GA 31405
912-819-5778
www.sjchs.org



Winship Cancer Institute of Emory University
1365 Clifton Road NE
Building C
Atlanta, GA 30322
winshipcancer.emory.edu

**Clinical trials are research studies that involve people. These studies test new ways to prevent, detect, diagnose, or treat diseases. People who take part in cancer clinical trials have an opportunity to contribute to scientists’ knowledge about cancer and to help in the development of improved cancer treatments. They also receive state-of-the-art care from cancer experts... Click here to learn more about clinical trials.